1. beginnerhuman-checked
Audit the evidence map
Read abstracts and verify country, year, K13 mutation, treatment regimen, and measured outcome. No biology training is required.
Deliverable
A checked extraction sheet covering 0 relevant papers from 1 sources.
Validation: A malaria researcher reviews disputed labels; every row retains a source link.
2. analysthuman-checked
Map where resistance signals diverge
Compare mutation prevalence, delayed-clearance measures, and treatment outcomes across East African locations and years.
Deliverable
A country-by-year evidence table with missing-data flags and contradiction notes.
Validation: Cathedral cross-checks values against the quoted passage and a second reviewer confirms exceptions.
3. specialisthuman-checked
Challenge the strongest mechanism
Evaluate whether K13 structure, parasite stress responses, partner-drug resistance, or transmission fitness best explains the observed pattern.
Deliverable
A falsifiable mechanism comparison and the smallest decisive experiment or analysis.
Validation: Domain experts score assumptions, feasibility, and whether the proposed test separates rival explanations.
4. agenthuman-checked
Run a monitored evidence sweep
Delegate citation chasing, mutation normalization, contradictory-result detection, and weekly literature surveillance to Cathedral agents.
Deliverable
A traceable update bundle with sources, extracted claims, uncertainty, and changes since the previous run.
Validation: Nothing becomes project evidence until a person approves the agent output.