Explore what humanity knows.
Investigate what it doesn’t.
Meaningful, reviewed changes in scientific knowledge.
No reviewed changes meet the significance threshold yet.
Explore the paper index or open a research run to investigate a question.
From the archive
A historical sweet-wormwood preparation later informed a modern extraction strategy during Project 523. The record did not contain modern pharmacology; experimental science established artemisinin’s chemistry, efficacy, and limits.
How we got hereAncient fever record
Historical observation
Project 523
Historical observation
Low-temperature extraction
Modern experimental science
Artemisinin
Modern experimental science
ACT therapy
Modern experimental science
Questions the current evidence has not resolved—and the evidence that would move them forward.
Cathedral looks for older observations, methods, and terminology that resemble modern work. Similarity is a lead for human review—not an accusation and not proof of influence.
Search the archiveResistance
Current evidence
Today’s frontier
Current evidence
Explanatory timeline · open the research record for sources and uncertainty.
NCI RAS Initiative · Cathedral editorial seed · Open