Live research / observational_science
A rigorous anomaly-research program for defining the metadata, calibration, sensor-fusion, chain-of-custody, and null-hypothesis tests required before an unidentified observation can support a scientific claim.
Progress summary
Chartered as a data-quality and inference problem, not as a claim about extraterrestrial origin.
Start here / no biology credential required
Cathedral does not claim one person can solve resistance from a browser. It makes the research legible, separates safe beginner work from specialist judgment, keeps every claim attached to evidence, and routes the hard decisions to biologists, clinicians, epidemiologists, and monitored agents.
1 / Orient
Read the ELI5 concept layer for malaria, ACT treatment, K13, and delayed parasite clearance.
2 / Search
Choose an open question and pull live PubMed, Europe PMC, Semantic Scholar, Crossref, and arXiv evidence.
3 / Contribute
Audit study location, mutation, regimen, outcome, and source passage in a structured evidence table.
4 / Validate
Send disputed interpretations and proposed interventions to domain experts; agents handle repeatable surveillance.
Structural biology
Wildtype structures load from AlphaFold DB. Resistance mutants are folded with ESMFold and rendered inline so molecular hypotheses can sit beside the literature.
Ghost nodes
Define calibration state, geolocation, timing, atmospheric context, sensor settings, processing history, and chain of custody.
Open canonical question record
Candidate explanations should include optical, atmospheric, platform, processing, human-perception, and adversarial causes before exotic hypotheses.
Open canonical question record
A defensible pipeline must preserve raw measurements, model instrument error, expose transformations, and report alternative explanations.
Open canonical question record
Daily progress log
Problem decomposition
Tier 1
Apply the migration to load the full seeded decomposition.
Tier 2
Apply the migration to load the full seeded decomposition.
Tier 3
Apply the migration to load the full seeded decomposition.
Tier 4
Apply the migration to load the full seeded decomposition.