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PfKelch13 is a Plasmodium falciparum Kelch-repeat protein associated with artemisinin resistance. Validated mutations such as C580Y, R539T, and I543T are linked to delayed parasite clearance and may change protein interactions that affect artemisinin activation.
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Structural biology
Wildtype structures load from AlphaFold DB. Resistance mutants are folded with ESMFold and rendered inline so molecular hypotheses can sit beside the literature.
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