C
2026
Artemisinin Resistance added to Cathedral for structured exploration.
This node can now collect papers, discussions, digests, and open questions.
Cathedral
Explore / global_health
1 explorers / 0 open questions / 0 papers
Artemisinin resistance in Plasmodium falciparum is most often linked to mutations in the PfKelch13 protein, especially C580Y. Cathedral is tracking the molecular mechanism, regional spread, treatment-pattern drivers, and candidate combination therapies as one connected research project.
Known nodes connect to ghost nodes where questions remain open.
Structural biology
Wildtype structures load from AlphaFold DB. Resistance mutants are folded with ESMFold and rendered inline so molecular hypotheses can sit beside the literature.
Credit follows documented contributions. Open questions remain attached to the historical path rather than being presented as context-free prompts.
2026
Artemisinin Resistance added to Cathedral for structured exploration.
This node can now collect papers, discussions, digests, and open questions.
Cathedral
Open questions
What is the strongest current explanation of Artemisinin Resistance?
0 researchers / 0 stakes
Open research workspace
Which assumptions about Artemisinin Resistance are still unresolved?
0 researchers / 0 stakes
Open research workspace
What evidence would most change how we understand Artemisinin Resistance?
0 researchers / 0 stakes
Open research workspace
Can community health worker treatment patterns be mapped to predict where resistance will emerge next?
0 researchers / 0 stakes
Open research workspace
Why does C580Y specifically dominate resistance while other K13 mutations have variable effects?
0 researchers / 0 stakes
Open research workspace
What is the exact molecular mechanism by which K13 mutations reduce artemisinin activation?
0 researchers / 0 stakes
Open research workspace
What is the fitness cost of K13 mutations in the absence of artemisinin drug pressure?
0 researchers / 0 stakes
Open research workspace
Are K13-independent resistance mechanisms emerging in East Africa?
0 researchers / 0 stakes
Open research workspace
Why is resistance spreading faster in Uganda than in Tanzania despite similar artemisinin use patterns?
0 researchers / 0 stakes
Open research workspace
What combination drug regimens can overcome K13-mediated partial resistance without requiring new drug development?
0 researchers / 0 stakes
Open research workspace
Ghost nodes
Are K13-independent resistance mechanisms emerging in East Africa?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.
openCan community health worker treatment patterns be mapped to predict where resistance will emerge next?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhat combination drug regimens can overcome K13-mediated partial resistance without requiring new drug development?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhat evidence would most change how we understand Artemisinin Resistance?
earl / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhat is the exact molecular mechanism by which K13 mutations reduce artemisinin activation?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhat is the fitness cost of K13 mutations in the absence of artemisinin drug pressure?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhat is the strongest current explanation of Artemisinin Resistance?
earl / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhich assumptions about Artemisinin Resistance are still unresolved?
earl / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhy does C580Y specifically dominate resistance while other K13 mutations have variable effects?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.
openWhy is resistance spreading faster in Uganda than in Tanzania despite similar artemisinin use patterns?
Cathedral concept synthesis / 0 active
Canonicalized from an unresolved question attached to this concept.