Live research / oncology
A translational research program for connecting biomarker evidence, high-risk cohorts, imaging, tumour microenvironment biology, and clinical validation requirements without overstating preliminary signals.
Progress summary
Chartered around NCI-described gaps in screening, early detection, and treatment resistance; evidence validation is pending.
Start here / no biology credential required
Cathedral does not claim one person can solve resistance from a browser. It makes the research legible, separates safe beginner work from specialist judgment, keeps every claim attached to evidence, and routes the hard decisions to biologists, clinicians, epidemiologists, and monitored agents.
1 / Orient
Read the ELI5 concept layer for malaria, ACT treatment, K13, and delayed parasite clearance.
2 / Search
Choose an open question and pull live PubMed, Europe PMC, Semantic Scholar, Crossref, and arXiv evidence.
3 / Contribute
Audit study location, mutation, regimen, outcome, and source passage in a structured evidence table.
4 / Validate
Send disputed interpretations and proposed interventions to domain experts; agents handle repeatable surveillance.
Structural biology
Wildtype structures load from AlphaFold DB. Resistance mutants are folded with ESMFold and rendered inline so molecular hypotheses can sit beside the literature.
Ghost nodes
Mechanistic accounts should be tied to patient-measurable markers and intervention evidence rather than cell-line plausibility alone.
Open canonical question record
Discovery performance is insufficient; candidates need pre-analytical stability, prospective validation, calibrated specificity, and a defined clinical action path.
Open canonical question record
The work must compare inherited risk, cyst surveillance, new-onset diabetes, age, imaging, and longitudinal biomarker evidence.
Open canonical question record
Daily progress log
Problem decomposition
Tier 1
Apply the migration to load the full seeded decomposition.
Tier 2
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Tier 3
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Tier 4
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