Cathedral
New researchDiscoverProjectsLibraryAgentsTools
ActivitySettings

Evidence, people, agents, and tools in one research record.

Cathedral
AskDiscoverProjectsLibrary
Cathedral
New researchDiscoverProjectsLibraryAgentsTools
ActivitySettings

Evidence, people, agents, and tools in one research record.

Cathedral

Open questions

Work on what knowledge has not answered.

A ghost node is a testable unknown with lineage, a resolution contract, evidence, active investigations, independent review, and contributor credit.

Open

59

Ready for investigation

Investigating

0

Workspaces in progress

Resolution record

0

Under review or resolved

Preserve an unanswered questionType A: historical / Type B: structural

Creation preserves a question. Resolution still requires evidence, completed work, and independent review.

Canonical registry

Questions with a resolution contract

These records are durable. Their state can change only through evidence, completed investigation, and review.

Historical questionopen

How can disruption prediction and control be validated across machines rather than tuned to one tokamak?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

Fusion Plasma Exhaust

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

Which plasma-facing material system can survive reactor-relevant heat, neutron damage, and maintenance cycles?

The reason this question remains open has not been recorded yet.

Type B gap audit

Look for the question nobody wrote down.

Cathedral inspects definitions, scales, boundary conditions, shared assumptions, and missing discriminating measurements. Outputs remain candidates until a person validates and promotes them.

No private gap candidates yet. Run an audit or generate a decomposition from a research workspace.

AskDiscoverProjectsLibrary

Answered when: A steward must define the evidence required for resolution.

Fusion Plasma Exhaust

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

What heat-exhaust architecture remains maintainable at power-plant duty cycles?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

Fusion Plasma Exhaust

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

Which tumour-microenvironment mechanisms are most responsible for treatment resistance and can be measured in patients?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

Pancreatic Cancer Early Detection

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

Which biomarker combinations can detect pancreatic cancer early enough to improve outcomes in a defined high-risk population?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

Pancreatic Cancer Early Detection

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

How should high-risk cohorts be selected so screening benefit exceeds false-positive harm?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

Pancreatic Cancer Early Detection

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

What minimum metadata makes a multi-sensor anomaly scientifically interpretable?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

UAP Evidence Standards

2023 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

Which preregistered null-hypothesis tests best separate ordinary artifacts from genuinely unresolved observations?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

UAP Evidence Standards

2023 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

How should sensor-fusion pipelines quantify uncertainty and disagreement between instruments?

The reason this question remains open has not been recorded yet.

Answered when: A steward must define the evidence required for resolution.

UAP Evidence Standards

2023 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Historical questionopen

What observation could decisively distinguish major theories of consciousness?

Competing theories often accommodate overlapping experimental results.

Answered when: A steward must define the evidence required for resolution.

The Hard Problem of Consciousness

1995 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

What observable signature could discriminate competing microscopic accounts of Hawking radiation?

Analogue systems test aspects of the kinematics, but direct astrophysical discrimination remains open.

Answered when: A steward must define the evidence required for resolution.

Hawking Radiation

1975 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

How is information preserved in a complete quantum description of black-hole evaporation?

The tension between semiclassical evaporation and unitary quantum evolution remains unresolved at the level of a complete, experimentally grounded theory.

Answered when: A steward must define the evidence required for resolution.

Hawking Radiation

1976 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

How can a capable learned system provide faithful, causally grounded explanations of its decisions?

Performance has advanced faster than dependable mechanistic interpretation.

Answered when: A steward must define the evidence required for resolution.

Machine Learning

1959 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionreopened

What formal conditions make learned systems generalize reliably outside their training distribution?

Modern systems amplify the original learning-machine question: when does learned behavior remain dependable in unfamiliar conditions?

Answered when: A steward must define the evidence required for resolution.

Machine Learning

1950 / 0 active researchers

New evidence invalidated or qualified the former resolution.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

How can off-target and unintended on-target edits be predicted across diverse human genomes?

Sequence context, cell state, repair pathway, and measurement sensitivity still limit universal prediction.

Answered when: A steward must define the evidence required for resolution.

CRISPR-Cas9

2012 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

How can genome editors be delivered safely and precisely to every clinically relevant tissue?

Delivery, immune response, tissue specificity, and manufacturability remain coupled bottlenecks.

Answered when: A steward must define the evidence required for resolution.

CRISPR-Cas9

2012 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

Why and how does physical information processing give rise to subjective experience?

No agreed bridge principle connects objective mechanism to phenomenal experience.

Answered when: A steward must define the evidence required for resolution.

The Hard Problem of Consciousness

1995 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

Which hardware-code-decoder combination reaches useful fault tolerance at realistic scale and cost?

Threshold theorems establish possibility, but system-level overhead and correlated noise remain decisive.

Answered when: A steward must define the evidence required for resolution.

Quantum Error Correction

1995 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Historical questionopen

Where does the periodic organization of superheavy elements depart from simple extrapolation?

Relativistic effects and short lifetimes make the chemistry of the heaviest elements difficult to establish.

Answered when: A steward must define the evidence required for resolution.

Periodic System

1960 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 13, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Dark Matter?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Dark Matter

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Dark Matter are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Dark Matter

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Dark Matter?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Dark Matter

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What precise neural mechanisms generate the phenomenological ‘what it is like’ aspect of experience?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Consciousness

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Can a quantitative measure like Integrated Information (Φ) be empirically validated across species and artificial substrates?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Consciousness

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

How do different levels of consciousness (e.g., dreaming, anesthesia, minimally conscious state) map onto distinct dynamical regimes in the brain?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Consciousness

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What are the necessary and sufficient conditions for a system to possess self‑consciousness?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Consciousness

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

How might future AI architectures be designed to support higher‑order representations without merely simulating behavior?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Consciousness

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

How can we overcome acquired resistance to third-generation EGFR inhibitors in NSCLC?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Lung Cancer

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What are the precise epigenetic triggers for lung cancer in lifelong non-smokers?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Lung Cancer

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Can liquid biopsies reliably detect minimal residual disease (MRD) before radiological recurrence?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Lung Cancer

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

How does the lung microbiome influence the efficacy of immunotherapy?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Lung Cancer

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq== are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Https://www.youtube.com/shorts/ou0z8_ufyni?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Https://www.youtube.com/shorts/ou0z8_ufyni

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Https://www.youtube.com/shorts/ou0z8_ufyni are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Https://www.youtube.com/shorts/ou0z8_ufyni

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Https://www.youtube.com/shorts/ou0z8_ufyni?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Https://www.youtube.com/shorts/ou0z8_ufyni

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Sleep?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Sleep

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Sleep are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Sleep

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Sleep?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Sleep

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Was The Big Bang Really The Start? What Other Scenarios Are Their??

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Was The Big Bang Really The Start? What Other Scenarios Are Their?

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Was The Big Bang Really The Start? What Other Scenarios Are Their? are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Was The Big Bang Really The Start? What Other Scenarios Are Their?

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Was The Big Bang Really The Start? What Other Scenarios Are Their??

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Was The Big Bang Really The Start? What Other Scenarios Are Their?

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Fasting?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Fasting

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Fasting are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Fasting

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Fasting?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Fasting

2026 / 1 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the strongest current explanation of Artemisinin Resistance?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Which assumptions about Artemisinin Resistance are still unresolved?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What evidence would most change how we understand Artemisinin Resistance?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Can community health worker treatment patterns be mapped to predict where resistance will emerge next?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Why does C580Y specifically dominate resistance while other K13 mutations have variable effects?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the exact molecular mechanism by which K13 mutations reduce artemisinin activation?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What is the fitness cost of K13 mutations in the absence of artemisinin drug pressure?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Are K13-independent resistance mechanisms emerging in East Africa?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

Why is resistance spreading faster in Uganda than in Tanzania despite similar artemisinin use patterns?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record
Structural gapopen

What combination drug regimens can overcome K13-mediated partial resistance without requiring new drug development?

This structural gap was preserved from the concept's unresolved-question record.

Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.

Artemisinin Resistance

2026 / 0 active researchers

Open for a bounded, evidence-backed investigation.

Reviewed Jul 31, 2026

Open research record