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Open questions 8

Historical question / open

How can disruption prediction and control be validated across machines rather than tuned to one tokamak?

Preserved from ITER MHD, Disruptions and Control Topical Group.

Historical question / open

Which plasma-facing material system can survive reactor-relevant heat, neutron damage, and maintenance cycles?

Preserved from ITER.

Historical question / open

What heat-exhaust architecture remains maintainable at power-plant duty cycles?

Preserved from ITER.

Historical question / open

Which tumour-microenvironment mechanisms are most responsible for treatment resistance and can be measured in patients?

Preserved from US National Cancer Institute.

Historical question / open

Which biomarker combinations can detect pancreatic cancer early enough to improve outcomes in a defined high-risk population?

Preserved from US National Cancer Institute.

Historical question / open

How should high-risk cohorts be selected so screening benefit exceeds false-positive harm?

Preserved from US National Cancer Institute.

Historical question / open

What minimum metadata makes a multi-sensor anomaly scientifically interpretable?

Preserved from NASA UAP Independent Study.

Historical question / open

Which preregistered null-hypothesis tests best separate ordinary artifacts from genuinely unresolved observations?

Preserved from NASA UAP Independent Study.